Prime Medicine 1 article

The scientific identity of Prime Medicine comes from prime editing, with search-and-replace genome editing extending genome modification toward a specific cell, tissue or disease context. Its editing stack links PEGRNA-guided gene correction to genetic disease correction without double-strand breaks; small insertion and deletion editing shows how programmable DNA modification is implemented in a specific tissue or therapeutic workflow. CRISPR systems, editing chemistries and therapeutic products remain separate tags; the editing platform of Prime Medicine also includes ex vivo hematopoietic stem cell editing.