Polygenic score 1 article

Polygenic score is defined here as a polygenic risk-scoring method centered on polygenic risk score and a clearly bounded biotechnology role. Its mechanism and use are captured by genome-wide variant aggregation and weighted genetic risk score, together with GWAS-derived variant weights and common-variant genetic burden, without expanding the tag to every related technology. A polygenic score is a statistical genomic measure rather than a diagnostic test, and its performance can vary substantially across ancestries and study populations.