PROTAC 1 article

In this taxonomy, PROTAC denotes a bifunctional targeted-protein-degrader modality organized around bifunctional protein degrader and its associated workflow. Researchers encounter it through E3 ligase recruiting molecule and target protein ligand, with linker-mediated ternary complex shaping the resulting effect or readout and ubiquitin-proteasome degradation providing another application context. A PROTAC is one engineered form of targeted protein degradation and is structurally distinct from single-molecule molecular glues.