Targeted protein degradation 1 article

The biotechnology identity of targeted protein degradation comes from ubiquitin-proteasome system recruitment, which places it within induced-proximity protein-removal strategy rather than a general field label. The defining chain runs from E3 ligase-mediated degradation through induced proximity pharmacology to degrader drug discovery, while removal of disease proteins indicates an important use case without changing the entity's core identity. Targeted protein degradation is the umbrella strategy; PROTACs and molecular glues are two different ways to recruit cellular degradation machinery.