Cellular senescence 1 article

cellular senescence denotes a durable cell state in which proliferation stops while signaling and metabolism remain active with a specific role in aging biology and geroscience. A typical implementation combines stable cell-cycle arrest with senescence-associated secretory phenotype, with SASP inflammatory signaling shaping the resulting molecular, cellular or analytical outcome. Cellular senescence is a cell state, whereas senolytics are interventions designed to remove senescent cells and senomorphics attempt to alter their secretory behavior.