Whole exome sequencing opens new ground in pharmacogenomics
A whole exome sequencing workflow now lets researchers analyze both coding and non-coding variants tied to drug response and safety, pushing past the limits of targeted panels.
Pharmacogenomics 1 article
A focus on genotype-guided drug therapy separates pharmacogenomics from adjacent concepts and identifies it as a pharmacogenomics field. From implementation to interpretation, genetic variation in drug response and drug metabolism genetics describe the core process, whereas CYP enzyme genotyping and transporter gene variation define how the result is used. Pharmacogenomics focuses on drug-response genetics and differs from disease-risk genomics, carrier screening and tumor somatic profiling.