Protein design 1 article

Sequence-to-structure design helps define protein design as a protein-engineering discipline with a bounded biological or analytical function. Its scientific boundary is set by sequence-to-structure design, structure-conditioned sequence design and protein stability engineering, while protein binding interface design identifies one research or clinical setting in which the concept is encountered. Protein design is broader than de novo protein design because it also includes optimization or redesign of existing proteins, not only creation of previously unobserved folds and sequences.