Metabolic engineering pushes CAR T cell therapy into new territory
A new review in Nature Reviews Cancer argues that the metabolic state of CAR T cells is the key to making them last longer and hit harder, especially against solid tumors.
Metabolic engineering 1 article
metabolic engineering occupies a distinct place in synthetic biology and biological manufacturing as an engineering strategy that redirects cellular metabolism toward desired products. Understanding the entity requires connecting cellular pathway redesign to flux balance optimization, with biosynthetic pathway engineering adding a key design, measurement or mechanistic dimension. The taxonomy keeps the concept level distinct, with cellular pathway redesign and flux balance optimization serving as characteristics rather than alternative names for metabolic engineering.